Assay Detail
Functional
CHEMBL697594
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tumor necrosis factor-alpha release from activated human monocyte cells in the presence of RP73401.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.51 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54988 | — | — | 1 | 9.15 |
| CHEMBL54767 | — | — | 1 | 9.15 |
| CHEMBL429356 | — | — | 1 | 9.05 |
| CHEMBL301448 | — | — | 1 | 8.82 |
| CHEMBL300395 | — | — | 1 | 8.70 |
| CHEMBL54361 | — | — | 1 | 8.52 |
| CHEMBL294831 | — | — | 1 | 8.52 |
| CHEMBL55867 | — | — | 1 | 8.52 |
| CHEMBL53710 | — | — | 1 | 8.52 |
| CHEMBL52712 | — | — | 1 | 8.52 |
| CHEMBL55203 | — | — | 1 | 8.52 |
| CHEMBL301201 | — | — | 1 | 8.40 |
| CHEMBL299332 | — | — | 1 | 8.10 |
| CHEMBL54590 | — | — | 1 | 8.00 |
| CHEMBL55046 | — | — | 1 | 7.98 |
| CHEMBL417930 | — | — | 1 | 7.75 |
| CHEMBL445354 | — | — | 1 | - |
| CHEMBL56406 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54988 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL54767 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL429356 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL301448 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL300395 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL54361 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL294831 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL55867 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL53710 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL52712 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL55203 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL301201 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL299332 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL54590 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL55046 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL417930 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL445354 | — | IC50 | > | 1.0 | nM | - |
| CHEMBL56406 | — | IC50 | < | 1.0 | nM | - |