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Assay Detail

CHEMBL697605

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory activity against interleukin-1 (IL-1) synthesis, using intact human monocytes
ChEMBL ↗
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis
Gallagher TF, Fier-Thompson SM, Garigipati R, Sorenson ME, Smietana JM, Lee D, Bender PE, Lee JC, Laydon JT, Griswold DE, Chabot-Fletcher MC, Breton JJ, Adams JL
Bioorg Med Chem Lett (1995) 5 : 1171 -1176
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 58 6.38 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL17736 — — 1 7.30
CHEMBL17331 PD-169316 — 1 7.30
CHEMBL17210 — — 1 7.30
CHEMBL278041 SB-202190 — 1 7.30
CHEMBL17445 — — 1 7.30
CHEMBL17389 — — 1 7.10
CHEMBL417087 — — 1 7.10
CHEMBL10 SB-203580 — 1 7.10
CHEMBL17396 — — 1 7.00
CHEMBL17334 — — 1 6.92
CHEMBL277724 — — 1 6.92
CHEMBL17346 — — 1 6.72
CHEMBL280317 — — 1 6.70
CHEMBL17293 — — 1 6.70
CHEMBL17493 — — 1 6.57
CHEMBL17570 — — 1 6.54
CHEMBL416169 — — 1 6.52
CHEMBL16925 — — 1 6.46
CHEMBL17325 — — 1 6.46
CHEMBL17722 — — 1 6.43
CHEMBL276063 — — 1 6.40
CHEMBL17148 — — 1 6.38
CHEMBL280265 — — 1 6.37
CHEMBL17480 — — 1 6.36
CHEMBL6252 — — 1 6.30
CHEMBL17224 — — 1 6.30
CHEMBL17688 — — 1 6.26
CHEMBL17370 — — 1 6.24
CHEMBL17238 — — 1 6.23
CHEMBL17158 — — 1 6.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL17736 — IC50 = 50.0 nM 7.30
CHEMBL17445 — IC50 = 50.0 nM 7.30
CHEMBL278041 SB-202190 IC50 = 50.0 nM 7.30
CHEMBL17331 PD-169316 IC50 = 50.0 nM 7.30
CHEMBL17210 — IC50 = 50.0 nM 7.30
CHEMBL17389 — IC50 = 80.0 nM 7.10
CHEMBL417087 — IC50 = 80.0 nM 7.10
CHEMBL10 SB-203580 IC50 = 80.0 nM 7.10
CHEMBL17396 — IC50 = 100.0 nM 7.00
CHEMBL17334 — IC50 = 120.0 nM 6.92
CHEMBL277724 — IC50 = 120.0 nM 6.92
CHEMBL17346 — IC50 = 190.0 nM 6.72
CHEMBL280317 — IC50 = 200.0 nM 6.70
CHEMBL17293 — IC50 = 200.0 nM 6.70
CHEMBL17493 — IC50 = 270.0 nM 6.57
CHEMBL17570 — IC50 = 290.0 nM 6.54
CHEMBL416169 — IC50 = 300.0 nM 6.52
CHEMBL16925 — IC50 = 350.0 nM 6.46
CHEMBL17325 — IC50 = 350.0 nM 6.46
CHEMBL17722 — IC50 = 370.0 nM 6.43
CHEMBL276063 — IC50 = 400.0 nM 6.40
CHEMBL17148 — IC50 = 420.0 nM 6.38
CHEMBL280265 — IC50 = 430.0 nM 6.37
CHEMBL17480 — IC50 = 440.0 nM 6.36
CHEMBL17224 — IC50 = 500.0 nM 6.30
CHEMBL6252 — IC50 = 500.0 nM 6.30
CHEMBL17688 — IC50 = 550.0 nM 6.26
CHEMBL17370 — IC50 = 580.0 nM 6.24
CHEMBL17238 — IC50 = 590.0 nM 6.23
CHEMBL17158 — IC50 = 600.0 nM 6.22
CHEMBL17252 — IC50 = 600.0 nM 6.22
CHEMBL17273 — IC50 = 620.0 nM 6.21
CHEMBL17204 — IC50 = 640.0 nM 6.19
CHEMBL276114 — IC50 = 650.0 nM 6.19
CHEMBL275365 — IC50 = 650.0 nM 6.19
CHEMBL17220 — IC50 = 680.0 nM 6.17
CHEMBL276529 — IC50 = 700.0 nM 6.16
CHEMBL277587 — IC50 = 710.0 nM 6.15
CHEMBL16911 — IC50 = 710.0 nM 6.15
CHEMBL17792 — IC50 = 740.0 nM 6.13
CHEMBL16926 — IC50 = 740.0 nM 6.13
CHEMBL17023 — IC50 = 770.0 nM 6.11
CHEMBL16838 — IC50 = 820.0 nM 6.09
CHEMBL280457 — IC50 = 860.0 nM 6.07
CHEMBL17641 — IC50 = 930.0 nM 6.03
CHEMBL280239 — IC50 = 1000.0 nM 6.00
CHEMBL17135 — IC50 = 1140.0 nM 5.94
CHEMBL17482 — IC50 = 1320.0 nM 5.88
CHEMBL279767 — IC50 = 2300.0 nM 5.64
CHEMBL17410 — IC50 = 2770.0 nM 5.56