Assay Detail
Functional
CHEMBL697826
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Effective concentration against Hepatitis B virus in human hepatoblastoma cell line
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hepatoblastoma cell line |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Does the anti-hepatitis B virus activity of (+)-5'-noraristeromycin exist in its 4'-epimer and 4'-deoxygenated derivatives?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.69 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 7.16 |
| CHEMBL301499 | — | — | 1 | 6.92 |
| CHEMBL2311158 | — | — | 1 | 6.84 |
| CHEMBL129014 | NORARISTEROMYCIN | — | 1 | 5.85 |
| CHEMBL2051948 | — | — | 1 | - |
| CHEMBL304978 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL141 | LAMIVUDINE | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL301499 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2311158 | — | EC50 | = | 145.0 | nM | 6.84 |
| CHEMBL129014 | NORARISTEROMYCIN | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2051948 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL304978 | — | EC50 | > | 10000.0 | nM | - |