Assay Detail
Binding
CHEMBL697882
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Binding affinity for Ionotropic glutamate receptor AMPA using [3H]- AMPA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.47 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | — | 1 | 7.40 |
| CHEMBL104208 | — | — | 1 | 6.89 |
| CHEMBL321164 | — | — | 1 | 6.82 |
| CHEMBL317234 | — | — | 1 | 6.57 |
| CHEMBL107160 | — | — | 1 | 5.58 |
| CHEMBL320290 | — | — | 1 | 5.57 |
| CHEMBL104197 | — | — | 1 | - |
| CHEMBL104065 | — | — | 1 | - |
| CHEMBL102612 | — | — | 1 | - |
| CHEMBL323289 | — | — | 1 | - |
| CHEMBL104039 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL104208 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL321164 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL317234 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL107160 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL320290 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL104197 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL104065 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL102612 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL323289 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL104039 | — | IC50 | > | 100000.0 | nM | - |