Assay Detail
Binding
CHEMBL697885
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity by measuring displacement of [3H]AMPA from Ionotropic glutamate receptor AMPA in rat cortical slice preparation
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Excitatory amino acid receptor atagonists: synthesis and pharmacology of 3-(carboxymethoxy)isoxazoles derived from AMPA
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.62 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | — | 1 | 7.40 |
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 5.40 |
| CHEMBL291274 | — | — | 1 | 4.05 |
| CHEMBL46859 | — | — | 1 | - |
| CHEMBL280585 | — | — | 1 | - |
| CHEMBL45051 | — | — | 1 | - |
| CHEMBL42885 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL275040 | KAINIC ACID | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL291274 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL46859 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL280585 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL45051 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL42885 | — | IC50 | > | 100000.0 | nM | - |