Assay Detail
Binding
CHEMBL697891
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Compound was evaluated for binding affinity at Ionotropic glutamate receptor AMPA using [3H]AMPA as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacology of a new AMPA-kainate receptor agonist with potent convulsant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.83 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276815 | (S)-AMPA | — | 1 | 7.40 |
| CHEMBL125440 | — | — | 1 | 5.89 |
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 5.40 |
| CHEMBL340591 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276815 | (S)-AMPA | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL125440 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL275040 | KAINIC ACID | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL340591 | — | IC50 | = | 24700.0 | nM | 4.61 |