Assay Detail
Binding
CHEMBL697923
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Inhibitory activity against IKK2
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL1991) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A novel series of potent and selective IKK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.00 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131693 | — | — | 1 | 7.96 |
| CHEMBL335949 | — | — | 1 | 7.58 |
| CHEMBL133548 | — | — | 1 | 7.51 |
| CHEMBL133823 | — | — | 1 | 7.37 |
| CHEMBL132416 | — | — | 1 | 7.36 |
| CHEMBL130631 | — | — | 1 | 7.32 |
| CHEMBL424069 | — | — | 1 | 7.23 |
| CHEMBL129981 | — | — | 1 | 7.22 |
| CHEMBL334758 | — | — | 1 | 7.18 |
| CHEMBL341432 | — | — | 1 | 7.08 |
| CHEMBL134010 | — | — | 1 | 7.04 |
| CHEMBL133928 | — | — | 1 | 7.04 |
| CHEMBL133471 | — | — | 1 | 6.93 |
| CHEMBL337236 | — | — | 2 | 6.84 |
| CHEMBL132942 | — | — | 1 | 6.84 |
| CHEMBL130866 | — | — | 1 | 6.83 |
| CHEMBL411659 | — | — | 1 | 6.81 |
| CHEMBL338848 | — | — | 1 | 6.67 |
| CHEMBL130511 | — | — | 1 | 6.57 |
| CHEMBL334506 | — | — | 1 | 6.51 |
| CHEMBL336594 | — | — | 1 | 6.48 |
| CHEMBL133941 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131693 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL335949 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL133548 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL133823 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL132416 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL130631 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL424069 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL129981 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL334758 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL341432 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL134010 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL133928 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL133471 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL337236 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL132942 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL130866 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL411659 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL338848 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL130511 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL334506 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL336594 | — | IC50 | = | 331.0 | nM | 6.48 |
| CHEMBL133941 | — | IC50 | = | 513.0 | nM | 6.29 |
| CHEMBL337236 | — | IC50 | = | 550.0 | nM | 6.26 |