Assay Detail
Functional
CHEMBL698058
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dual antagonists of platelet activating factor and histamine. Identification of structural requirements for dual activity of N-Acyl-4-(5,6-dihydro-11H-benzo [5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.63 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280164 | APAFANT | 2.0 | 1 | 7.40 |
| CHEMBL10971 | SCH-37370 | — | 1 | 6.21 |
| CHEMBL344942 | — | — | 1 | 6.17 |
| CHEMBL142268 | — | — | 1 | 6.09 |
| CHEMBL143272 | — | — | 1 | 6.09 |
| CHEMBL342747 | — | — | 1 | 6.00 |
| CHEMBL143242 | — | — | 1 | 6.00 |
| CHEMBL140483 | — | — | 1 | 5.85 |
| CHEMBL297624 | — | — | 1 | 5.82 |
| CHEMBL139760 | — | — | 1 | 5.75 |
| CHEMBL116935 | — | — | 1 | 5.62 |
| CHEMBL131155 | — | — | 1 | 5.47 |
| CHEMBL334127 | — | — | 1 | 5.47 |
| CHEMBL358332 | — | — | 1 | 5.06 |
| CHEMBL325909 | — | — | 1 | 4.89 |
| CHEMBL140919 | — | — | 1 | 4.55 |
| CHEMBL331603 | — | — | 1 | 4.48 |
| CHEMBL334318 | — | — | 1 | 4.39 |
| CHEMBL124466 | — | — | 1 | - |
| CHEMBL141432 | — | — | 1 | - |
| CHEMBL946 | AZATADINE | 4.0 | 1 | - |
| CHEMBL998 | LORATADINE | 4.0 | 1 | - |
| CHEMBL140924 | — | — | 1 | - |
| CHEMBL342455 | — | — | 1 | - |
| CHEMBL341584 | — | — | 1 | - |
| CHEMBL505 | CHLORPHENIRAMINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280164 | APAFANT | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL10971 | SCH-37370 | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL344942 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL142268 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL143272 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL342747 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL143242 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL140483 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL297624 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL139760 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL116935 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL131155 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL334127 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL358332 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL325909 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL140919 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL331603 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL334318 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL124466 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL141432 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL946 | AZATADINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL998 | LORATADINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL140924 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL342455 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL341584 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL505 | CHLORPHENIRAMINE | IC50 | > | 50000.0 | nM | - |