Assay Detail
Binding
CHEMBL698078
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Ability to displace binding of [3H]AMPA to recombinant human Ionotropic glutamate receptor ionotropic kainate 1
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.71 | 6.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL542242 | — | — | 1 | 6.81 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | 2.0 | 1 | 5.38 |
| CHEMBL222519 | NBQX | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL542242 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL222519 | NBQX | Ki | = | 11600.0 | nM | 4.94 |