Assay Detail
Binding
CHEMBL698197
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In vitro inhibitory concentration required against recombinant human IkB kinase beta (IKK-beta)
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL1991) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel and selective IKK-beta serine-threonine protein kinase inhibitors. Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.82 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170406 | — | — | 1 | 6.30 |
| CHEMBL426403 | — | — | 1 | 6.30 |
| CHEMBL170463 | — | — | 1 | 6.22 |
| CHEMBL170563 | — | — | 1 | 6.22 |
| CHEMBL352549 | — | — | 1 | 6.22 |
| CHEMBL173484 | — | — | 1 | 6.22 |
| CHEMBL424766 | — | — | 1 | 6.16 |
| CHEMBL354947 | — | — | 1 | 6.16 |
| CHEMBL535135 | — | — | 1 | 6.10 |
| CHEMBL434691 | — | — | 1 | 6.05 |
| CHEMBL534692 | — | — | 1 | 6.00 |
| CHEMBL171291 | — | — | 1 | 6.00 |
| CHEMBL174201 | — | — | 1 | 5.85 |
| CHEMBL170189 | — | — | 1 | 5.85 |
| CHEMBL173050 | — | — | 1 | 5.82 |
| CHEMBL366730 | — | — | 1 | 5.77 |
| CHEMBL174140 | — | — | 1 | 5.75 |
| CHEMBL173111 | — | — | 1 | 5.70 |
| CHEMBL558038 | — | — | 1 | 5.60 |
| CHEMBL440200 | — | — | 1 | 5.60 |
| CHEMBL262056 | — | — | 1 | 5.52 |
| CHEMBL173747 | — | — | 1 | 5.28 |
| CHEMBL174430 | — | — | 1 | 5.26 |
| CHEMBL534462 | — | — | 1 | 4.82 |
| CHEMBL170024 | — | — | 1 | 4.70 |
| CHEMBL170355 | — | — | 1 | - |
| CHEMBL535358 | — | — | 1 | - |
| CHEMBL171587 | — | — | 1 | - |
| CHEMBL444345 | — | — | 1 | - |
| CHEMBL539837 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170406 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL426403 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL170463 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL170563 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL352549 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL173484 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL424766 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL354947 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL535135 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL434691 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL534692 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL171291 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL174201 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL170189 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL173050 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL366730 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL174140 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL173111 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL440200 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL558038 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL262056 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL173747 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL174430 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL534462 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL170024 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL352957 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL171680 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL424000 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL366530 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL535359 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL539837 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL444345 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL171587 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL535358 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL170355 | — | IC50 | > | 20000.0 | nM | - |