Assay Detail
Functional
CHEMBL698438
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Cytotoxicity against human hepatoma Hepa-G2
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor AHMA linked to DNA minor groove binding agents: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.70 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336442 | — | — | 1 | 7.10 |
| CHEMBL343088 | — | — | 1 | 7.10 |
| CHEMBL341709 | — | — | 1 | 6.34 |
| CHEMBL343222 | — | — | 1 | 6.20 |
| CHEMBL321473 | — | — | 1 | 5.85 |
| CHEMBL139229 | — | — | 1 | 5.38 |
| CHEMBL344053 | — | — | 1 | 5.16 |
| CHEMBL335568 | — | — | 1 | 4.17 |
| CHEMBL343337 | — | — | 1 | 4.00 |
| CHEMBL1161218 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336442 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL343088 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL341709 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL343222 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL321473 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL139229 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL344053 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL335568 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL343337 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1161218 | — | IC50 | > | 100000.0 | nM | - |