Assay Detail

CHEMBL698448

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Functional

Inhibition of lanosterol 14-alpha-demethylation in hepatic microsomes from human

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Tissue	Liver
Subcellular	Microsomes
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.

Walker KA, Kertesz DJ, Rotstein DM, Swinney DC, Berry PW, So OY, Webb AS, Watson DM, Mak AY, Burton PM.
J Med Chem (1993) 36 : 2235 -2237
PubMed 8340925 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	9.10	9.10

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL70611	AZALANSTAT	2.0	1	9.10

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL70611	AZALANSTAT	Ki	=	0.79	nM	9.10