Assay Detail
Binding
CHEMBL698529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]-kainic acid radioligand at kainate receptor in rat cortical membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate (CHEMBL2094119) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
(S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.10 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28472 | — | — | 1 | 5.80 |
| CHEMBL29024 | — | — | 1 | 4.85 |
| CHEMBL27130 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28472 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL29024 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL27130 | — | IC50 | = | 23000.0 | nM | 4.64 |