Assay Detail
Functional
CHEMBL698590
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was evaluated in vitro for the immunosuppressive activity in interleukin-2 by interleukin-2 reporter gene assay (IL2-RGA)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The role of water molecules in the structure-based design of (5-hydroxynorvaline)-2-cyclosporin: synthesis, biological activity, and crystallographic analysis with cyclophilin A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.73 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 8.30 |
| CHEMBL2107422 | GECLOSPORIN | 2.0 | 1 | 7.89 |
| CHEMBL384726 | — | — | 1 | 7.58 |
| CHEMBL415597 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2107422 | GECLOSPORIN | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL384726 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL415597 | — | IC50 | = | 70.0 | nM | 7.16 |