Assay Detail
Binding
CHEMBL698700
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against kainate receptor in rat brain membrane using [3H]kainate as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate (CHEMBL2094119) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.60 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9790 | — | — | 1 | 5.75 |
| CHEMBL13260 | YM-90K | — | 1 | 5.66 |
| CHEMBL222519 | NBQX | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9790 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL13260 | YM-90K | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL222519 | NBQX | Ki | = | 4100.0 | nM | 5.39 |