Assay Detail
Functional
CHEMBL698738
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for Ionotropic glutamate receptor AMPA antagonistic activity by measuring its ability to inhibit depolarizations induced by 40 uM AMPA in rat cortical slice preparation.
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Structure-activity studies of 6-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 2. Effects of distal acid bioisosteric substitution, absolute stereochemical preferences, and in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.95 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL309342 | — | — | 2 | 5.85 |
| CHEMBL70773 | — | — | 2 | 5.21 |
| CHEMBL307562 | — | — | 1 | 5.05 |
| CHEMBL71043 | — | — | 1 | 4.70 |
| CHEMBL73072 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL309342 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL70773 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL307562 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL71043 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL309342 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL73072 | — | IC50 | = | 68800.0 | nM | 4.16 |
| CHEMBL70773 | — | IC50 | > | 100000.0 | nM | - |