Assay Detail
Binding
CHEMBL698781
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Inhibition of human inosine monophosphate dehydrogenase IMPDH II
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Inosine-5'-monophosphate dehydrogenase 2 (CHEMBL2002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.38 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL152910 | — | — | 1 | 8.30 |
| CHEMBL150777 | — | — | 1 | 8.30 |
| CHEMBL23843 | — | — | 1 | 8.10 |
| CHEMBL347721 | — | — | 1 | 8.05 |
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 7.85 |
| CHEMBL150728 | — | — | 1 | 7.75 |
| CHEMBL65013 | — | — | 1 | 7.72 |
| CHEMBL356371 | — | — | 1 | 7.72 |
| CHEMBL153241 | — | — | 1 | 7.66 |
| CHEMBL345992 | — | — | 1 | 7.54 |
| CHEMBL153387 | — | — | 1 | 7.50 |
| CHEMBL153032 | — | — | 1 | 7.47 |
| CHEMBL153014 | — | — | 1 | 7.37 |
| CHEMBL153511 | — | — | 1 | 7.37 |
| CHEMBL151220 | — | — | 1 | 7.34 |
| CHEMBL153223 | — | — | 1 | 7.20 |
| CHEMBL153187 | — | — | 1 | 7.19 |
| CHEMBL359340 | — | — | 1 | 7.19 |
| CHEMBL424508 | — | — | 1 | 7.16 |
| CHEMBL150487 | — | — | 1 | 6.96 |
| CHEMBL151112 | — | — | 1 | 6.80 |
| CHEMBL358383 | — | — | 1 | 6.80 |
| CHEMBL153759 | — | — | 1 | 6.75 |
| CHEMBL346396 | — | — | 1 | 6.70 |
| CHEMBL357069 | — | — | 1 | 6.66 |
| CHEMBL359161 | — | — | 1 | 6.52 |
| CHEMBL149638 | — | — | 1 | - |
| CHEMBL152959 | — | — | 1 | - |
| CHEMBL358876 | — | — | 1 | - |
| CHEMBL153715 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL152910 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL150777 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL23843 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL347721 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL866 | MYCOPHENOLIC ACID | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL150728 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL65013 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL356371 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL153241 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL345992 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL153387 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL153032 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL153014 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL153511 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL151220 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL153223 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL153187 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL359340 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL424508 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL150487 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL151112 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL358383 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL153759 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL346396 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL357069 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL359161 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL149638 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL152959 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL358876 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL153715 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL152988 | — | IC50 | < | 5.0 | nM | - |