Assay Detail
Binding
CHEMBL698799
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In vitro for anti-HD2 (Histone deacetylase 2) activity in maize
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Zea mays |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.44 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.15 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.30 |
| CHEMBL51356 | — | — | 1 | 5.72 |
| CHEMBL51060 | — | — | 1 | 5.62 |
| CHEMBL13168 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL51356 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL51060 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL13168 | — | IC50 | = | 3800.0 | nM | 5.42 |