Assay Detail
Binding
CHEMBL698803
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of maize Histone deacetylase 2 (HD-2) activity
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Zea mays |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.81 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.52 |
| CHEMBL143327 | — | — | 1 | 7.00 |
| CHEMBL140000 | — | — | 1 | 7.00 |
| CHEMBL46942 | — | — | 1 | 7.00 |
| CHEMBL143802 | — | — | 1 | 6.85 |
| CHEMBL143734 | — | — | 1 | 6.82 |
| CHEMBL142988 | — | — | 1 | 6.75 |
| CHEMBL139999 | — | — | 1 | 6.75 |
| CHEMBL143047 | — | — | 1 | 6.52 |
| CHEMBL143849 | — | — | 1 | 6.05 |
| CHEMBL142305 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL143327 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL140000 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL46942 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL143802 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL143734 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL142988 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL139999 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL143047 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL143849 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL142305 | — | IC50 | = | 2000.0 | nM | 5.70 |