Assay Detail
Binding
CHEMBL698807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against histone deacetylase (HDAC4) prepared from mouse melanoma B16/BL6 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | B16/BL6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.42 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1790587 | — | — | 1 | 8.52 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.70 |
| CHEMBL1790586 | — | — | 1 | 7.13 |
| CHEMBL1790596 | — | — | 1 | 7.05 |
| CHEMBL1790599 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1790587 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1790586 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL1790596 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL1790599 | — | IC50 | = | 190.0 | nM | 6.72 |