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Assay Detail

CHEMBL698810

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Histone deacetylase 6 (HDAC6) of HeLa nuclear extracts
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Histone deacetylase 6 (CHEMBL1865)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group.
Wu TY, Hassig C, Wu Y, Ding S, Schultz PG.
Bioorg Med Chem Lett (2004) 14 : 449 -453
PubMed 14698179 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.78 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL98 VORINOSTAT 4.0 1 7.00
CHEMBL343717 1 6.22
CHEMBL336935 1 6.21
CHEMBL140525 1 6.11
CHEMBL141909 1 6.04
CHEMBL141082 1 5.55
CHEMBL137875 1 5.51
CHEMBL337584 1 5.37
CHEMBL139192 1 5.26
CHEMBL141885 1 4.52
CHEMBL138293 1 -
CHEMBL138626 1 -
CHEMBL138090 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL98 VORINOSTAT IC50 = 100.0 nM 7.00
CHEMBL343717 IC50 = 600.0 nM 6.22
CHEMBL336935 IC50 = 620.0 nM 6.21
CHEMBL140525 IC50 = 780.0 nM 6.11
CHEMBL141909 IC50 = 910.0 nM 6.04
CHEMBL141082 IC50 = 2800.0 nM 5.55
CHEMBL137875 IC50 = 3100.0 nM 5.51
CHEMBL337584 IC50 = 4300.0 nM 5.37
CHEMBL139192 IC50 = 5500.0 nM 5.26
CHEMBL141885 IC50 = 30000.0 nM 4.52
CHEMBL138293 IC50 > 100000.0 nM -
CHEMBL138626 IC50 > 100000.0 nM -
CHEMBL138090 IC50 > 100000.0 nM -