Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL698868

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was evaluated for the inhibition of human rhinovirus 3C protease (3CP)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human rhinovirus sp.
Confidence 1 — Organism
Curated By Intermediate

Target

Human rhinovirus sp. (CHEMBL612470)
Type ORGANISM
Organism Human rhinovirus sp.

Publication

Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors.
Dragovich PS, Zhou R, Webber SE, Prins TJ, Kwok AK, Okano K, Fuhrman SA, Zalman LS, Maldonado FC, Brown EL, Meador JW, Patick AK, Ford CE, Brothers MA, Binford SL, Matthews DA, Ferre RA, Worland ST.
Bioorg Med Chem Lett (2000) 10 : 45 -48
PubMed 10636240 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 10 6.32 8.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL145753 1 8.35
CHEMBL95007 1 8.22
CHEMBL407772 1 7.19
CHEMBL359383 1 6.77
CHEMBL359166 1 6.16
CHEMBL358738 1 5.77
CHEMBL358554 1 5.50
CHEMBL358959 1 5.46
CHEMBL145508 1 5.33
CHEMBL356572 1 4.47

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL145753 Ki = 4.5 nM 8.35
CHEMBL95007 Ki = 6.0 nM 8.22
CHEMBL407772 Ki = 65.0 nM 7.19
CHEMBL359383 Ki = 170.0 nM 6.77
CHEMBL359166 Ki = 700.0 nM 6.16
CHEMBL358738 Ki = 1700.0 nM 5.77
CHEMBL358554 Ki = 3200.0 nM 5.50
CHEMBL358959 Ki = 3500.0 nM 5.46
CHEMBL145508 Ki = 4700.0 nM 5.33
CHEMBL356572 Ki = 34000.0 nM 4.47