Assay Detail
Binding
CHEMBL698890
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human src kinase.
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrazolo[3,4-d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck -- a selectivity insight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.76 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47787 | — | — | 1 | 7.90 |
| CHEMBL416091 | — | — | 1 | 7.57 |
| CHEMBL43773 | — | — | 1 | 7.37 |
| CHEMBL46785 | — | — | 1 | 7.19 |
| CHEMBL295528 | — | — | 1 | 6.94 |
| CHEMBL295601 | — | — | 1 | 6.81 |
| CHEMBL297363 | — | — | 1 | 6.72 |
| CHEMBL45651 | — | — | 1 | 6.51 |
| CHEMBL45693 | — | — | 1 | 6.37 |
| CHEMBL417006 | — | — | 1 | 6.34 |
| CHEMBL46176 | — | — | 1 | 6.33 |
| CHEMBL45683 | — | — | 1 | 6.28 |
| CHEMBL402673 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47787 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL416091 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL43773 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL46785 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL295528 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL295601 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL297363 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL45651 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL45693 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL417006 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL46176 | — | IC50 | = | 463.0 | nM | 6.33 |
| CHEMBL45683 | — | IC50 | = | 526.0 | nM | 6.28 |
| CHEMBL402673 | — | IC50 | = | 3190.0 | nM | 5.50 |