Assay Detail
Binding
CHEMBL698901
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Human Leukocyte Elastase (HLE) as apparent binding constant (kreact/kinact)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alkoxy substituted benzisothiazolone (BIT) derivatives: potent inhibitors of human leukocyte elastase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 9.75 | 10.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12082 | — | — | 1 | 10.66 |
| CHEMBL11558 | — | — | 1 | 10.31 |
| CHEMBL430157 | — | — | 1 | 10.15 |
| CHEMBL12051 | — | — | 1 | 10.10 |
| CHEMBL11874 | — | — | 1 | 10.10 |
| CHEMBL269223 | — | — | 1 | 9.96 |
| CHEMBL11758 | — | — | 1 | 9.77 |
| CHEMBL11913 | — | — | 1 | 9.62 |
| CHEMBL274582 | — | — | 1 | 9.47 |
| CHEMBL274347 | — | — | 1 | 9.33 |
| CHEMBL416154 | — | — | 1 | 8.92 |
| CHEMBL274085 | — | — | 1 | 8.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12082 | — | Ki | = | 0.022 | nM | 10.66 |
| CHEMBL11558 | — | Ki | = | 0.049 | nM | 10.31 |
| CHEMBL430157 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL12051 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL11874 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL269223 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL11758 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL11913 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL274582 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL274347 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL416154 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL274085 | — | Ki | = | 2.7 | nM | 8.57 |