Assay Detail
Binding
CHEMBL698938
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cells
87
Total Activities
87
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Endothelial cell |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 87 | 7.32 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119501 | — | — | 1 | 9.00 |
| CHEMBL118113 | — | — | 1 | 8.85 |
| CHEMBL119733 | — | — | 1 | 8.70 |
| CHEMBL117198 | — | — | 1 | 8.70 |
| CHEMBL119335 | — | — | 1 | 8.42 |
| CHEMBL119039 | — | — | 1 | 8.40 |
| CHEMBL116152 | — | — | 1 | 8.40 |
| CHEMBL117746 | — | — | 1 | 8.40 |
| CHEMBL118034 | — | — | 1 | 8.30 |
| CHEMBL116070 | — | — | 1 | 8.30 |
| CHEMBL326271 | — | — | 1 | 8.30 |
| CHEMBL326120 | — | — | 1 | 8.30 |
| CHEMBL117279 | — | — | 1 | 8.30 |
| CHEMBL325184 | — | — | 1 | 8.22 |
| CHEMBL117894 | — | — | 1 | 8.22 |
| CHEMBL117668 | — | — | 1 | 8.22 |
| CHEMBL331584 | — | — | 1 | 8.10 |
| CHEMBL118518 | — | — | 1 | 8.05 |
| CHEMBL118886 | — | — | 1 | 8.00 |
| CHEMBL116089 | — | — | 1 | 7.89 |
| CHEMBL419046 | — | — | 1 | 7.80 |
| CHEMBL119183 | — | — | 1 | 7.80 |
| CHEMBL326771 | — | — | 1 | 7.77 |
| CHEMBL118074 | — | — | 1 | 7.77 |
| CHEMBL116307 | — | — | 1 | 7.75 |
| CHEMBL115971 | — | — | 1 | 7.75 |
| CHEMBL119732 | — | — | 1 | 7.70 |
| CHEMBL117453 | — | — | 1 | 7.70 |
| CHEMBL116454 | — | — | 1 | 7.66 |
| CHEMBL118022 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119501 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL118113 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL117198 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL119733 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL119335 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL119039 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL116152 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL117746 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL118034 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL116070 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL326271 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL326120 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL117279 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL117668 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL325184 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL117894 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL331584 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL118518 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL118886 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL116089 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL419046 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL119183 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL326771 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL118074 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL115971 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL116307 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL119732 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL117453 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL116454 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL118022 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL267678 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL115637 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL115431 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL115966 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL325651 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL119091 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL118299 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL117936 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL118089 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL324158 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL268567 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL118300 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL325033 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL116363 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL119886 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL117093 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL115815 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL117571 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL119815 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL117671 | — | IC50 | = | 116.0 | nM | 6.94 |