Assay Detail
Binding
CHEMBL698970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human VEGF-receptor 2 (kdr) kinase.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrazolo[3,4-d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck -- a selectivity insight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.46 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45651 | — | — | 1 | 6.58 |
| CHEMBL45683 | — | — | 1 | 6.36 |
| CHEMBL46785 | — | — | 1 | 5.42 |
| CHEMBL47787 | — | — | 1 | 4.47 |
| CHEMBL295528 | — | — | 1 | 4.46 |
| CHEMBL416091 | — | — | 1 | - |
| CHEMBL297363 | — | — | 1 | - |
| CHEMBL417006 | — | — | 1 | - |
| CHEMBL45693 | — | — | 1 | - |
| CHEMBL43773 | — | — | 1 | - |
| CHEMBL295601 | — | — | 1 | - |
| CHEMBL402673 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45651 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL45683 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL46785 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL47787 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL295528 | — | IC50 | = | 34600.0 | nM | 4.46 |
| CHEMBL416091 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL297363 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL417006 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL45693 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL43773 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL295601 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL402673 | — | IC50 | > | 50000.0 | nM | - |