Assay Detail
Functional
CHEMBL699057
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested in vitro for anticellular activity against HeLa S3 cell growth at 72-hour exposure.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New water-soluble duocarmycin derivatives: synthesis and antitumor activity of A-ring pyrrole compounds bearing beta-heteroarylacryloyl groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.11 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101995 | — | — | 1 | 9.59 |
| CHEMBL348326 | — | — | 1 | 9.55 |
| CHEMBL158368 | — | — | 1 | 9.38 |
| CHEMBL159124 | — | — | 1 | 9.05 |
| CHEMBL161770 | — | — | 1 | 8.54 |
| CHEMBL542770 | — | — | 1 | 7.43 |
| CHEMBL541110 | — | — | 1 | 7.05 |
| CHEMBL545580 | — | — | 1 | 6.96 |
| CHEMBL538554 | — | — | 1 | 6.82 |
| CHEMBL539574 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101995 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL348326 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL158368 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL159124 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL161770 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL542770 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL541110 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL545580 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL538554 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL539574 | — | IC50 | = | 170.0 | nM | 6.77 |