Assay Detail
Functional
CHEMBL699080
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H1-antihistamine activity on guinea pig ileum
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
N-benzylpiperazino derivatives of 3-nitro-4-hydroxycoumarin with H1 antihistamine and mast cell stabilizing properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 7.62 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL534 | KETOTIFEN | 4.0 | 1 | 9.50 |
| CHEMBL511 | PYRILAMINE | 4.0 | 1 | 9.10 |
| CHEMBL35376 | — | — | 1 | 9.00 |
| CHEMBL286017 | — | — | 1 | 8.40 |
| CHEMBL32097 | — | — | 1 | 8.30 |
| CHEMBL264756 | — | — | 1 | 7.90 |
| CHEMBL286094 | — | — | 1 | 6.80 |
| CHEMBL36517 | — | — | 1 | 5.60 |
| CHEMBL32953 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL534 | KETOTIFEN | Kd | = | 0.3162 | nM | 9.50 |
| CHEMBL511 | PYRILAMINE | Kd | = | 0.7943 | nM | 9.10 |
| CHEMBL35376 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL286017 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL32097 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL264756 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL286094 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL36517 | — | Kd | = | 2511.89 | nM | 5.60 |
| CHEMBL32953 | — | Kd | = | 100000.0 | nM | 4.00 |