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Assay Detail

CHEMBL699149

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Functional
In vitro antiviral activity against HRV serotype-14
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human rhinovirus sp.
Confidence 1 — Organism
Curated By Intermediate

Target

Human rhinovirus sp. (CHEMBL612470)
Type ORGANISM
Organism Human rhinovirus sp.

Publication

Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids.
Dragovich PS, Webber SE, Prins TJ, Zhou R, Marakovits JT, Tikhe JG, Fuhrman SA, Patick AK, Matthews DA, Ford CE, Brown EL, Binford SL, Meador JW, Ferre RA, Worland ST.
Bioorg Med Chem Lett (1999) 9 : 2189 -2194
PubMed 10465543 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 6.53 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL70012 1 7.52
CHEMBL262675 1 6.85
CHEMBL311162 1 6.80
CHEMBL68801 1 6.72
CHEMBL71788 1 6.70
CHEMBL305221 1 6.50
CHEMBL71839 1 6.40
CHEMBL71273 1 6.27
CHEMBL19648 1 6.27
CHEMBL68318 1 6.00
CHEMBL305210 1 5.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL70012 EC50 = 30.0 nM 7.52
CHEMBL262675 EC50 = 140.0 nM 6.85
CHEMBL311162 EC50 = 160.0 nM 6.80
CHEMBL68801 EC50 = 190.0 nM 6.72
CHEMBL71788 EC50 = 200.0 nM 6.70
CHEMBL305221 EC50 = 320.0 nM 6.50
CHEMBL71839 EC50 = 400.0 nM 6.40
CHEMBL71273 EC50 = 540.0 nM 6.27
CHEMBL19648 EC50 = 540.0 nM 6.27
CHEMBL68318 EC50 = 1000.0 nM 6.00
CHEMBL305210 EC50 = 1800.0 nM 5.75