Assay Detail
Functional
CHEMBL699267
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In vitro inhibition of HeLa S3 cell growth by 50% after 1 hr.
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and antitumor activity of duocarmycin derivatives: modification of segment-A of A-ring pyrrole compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 8.73 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319784 | — | — | 1 | 10.74 |
| CHEMBL316714 | — | — | 1 | 10.60 |
| CHEMBL35670 | — | — | 1 | 10.35 |
| CHEMBL431456 | — | — | 1 | 10.10 |
| CHEMBL100711 | — | — | 1 | 10.04 |
| CHEMBL419165 | — | — | 1 | 10.03 |
| CHEMBL101414 | — | — | 1 | 10.01 |
| CHEMBL328384 | — | — | 1 | 9.89 |
| CHEMBL321766 | — | — | 1 | 9.68 |
| CHEMBL320618 | — | — | 1 | 9.60 |
| CHEMBL328425 | — | — | 1 | 9.57 |
| CHEMBL320010 | — | — | 1 | 9.55 |
| CHEMBL101268 | — | — | 1 | 9.37 |
| CHEMBL443020 | — | — | 1 | 9.14 |
| CHEMBL431282 | — | — | 1 | 9.13 |
| CHEMBL102195 | — | — | 1 | 8.85 |
| CHEMBL317186 | — | — | 1 | 8.62 |
| CHEMBL317943 | — | — | 1 | 8.60 |
| CHEMBL327522 | — | — | 1 | 8.57 |
| CHEMBL317437 | — | — | 1 | 8.54 |
| CHEMBL101995 | — | — | 1 | 8.54 |
| CHEMBL102093 | — | — | 1 | 8.52 |
| CHEMBL100185 | — | — | 1 | 8.51 |
| CHEMBL319833 | — | — | 1 | 8.48 |
| CHEMBL102048 | — | — | 1 | 8.44 |
| CHEMBL310675 | — | — | 1 | 8.40 |
| CHEMBL99373 | — | — | 1 | 8.15 |
| CHEMBL100710 | — | — | 1 | 8.12 |
| CHEMBL100444 | — | — | 1 | 8.11 |
| CHEMBL316474 | — | — | 1 | 8.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319784 | — | IC50 | = | 0.018 | nM | 10.74 |
| CHEMBL316714 | — | IC50 | = | 0.025 | nM | 10.60 |
| CHEMBL35670 | — | IC50 | = | 0.045 | nM | 10.35 |
| CHEMBL431456 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL100711 | — | IC50 | = | 0.092 | nM | 10.04 |
| CHEMBL419165 | — | IC50 | = | 0.093 | nM | 10.03 |
| CHEMBL101414 | — | IC50 | = | 0.098 | nM | 10.01 |
| CHEMBL328384 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL321766 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL320618 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL328425 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL320010 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL101268 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL443020 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL431282 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL102195 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL317186 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL317943 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL327522 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL101995 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL317437 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL102093 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL100185 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL319833 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL102048 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL310675 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL99373 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL100710 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL100444 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL316474 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL317519 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL320207 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL102103 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL319900 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL100747 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL101064 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL318509 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL99857 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL100182 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL319667 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL433393 | — | IC50 | = | 130.0 | nM | 6.89 |