Assay Detail
Functional
CHEMBL699268
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In vitro inhibition HeLa S3 cell growth by 50% after 72 hr.
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and antitumor activity of duocarmycin derivatives: modification of segment-A of A-ring pyrrole compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 9.36 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419165 | — | — | 1 | 11.00 |
| CHEMBL316714 | — | — | 1 | 10.85 |
| CHEMBL101414 | — | — | 1 | 10.66 |
| CHEMBL102195 | — | — | 1 | 10.54 |
| CHEMBL100711 | — | — | 1 | 10.41 |
| CHEMBL431456 | — | — | 1 | 10.34 |
| CHEMBL317437 | — | — | 1 | 10.19 |
| CHEMBL328384 | — | — | 1 | 10.09 |
| CHEMBL320618 | — | — | 1 | 10.00 |
| CHEMBL321766 | — | — | 1 | 9.92 |
| CHEMBL320010 | — | — | 1 | 9.80 |
| CHEMBL99373 | — | — | 1 | 9.77 |
| CHEMBL431282 | — | — | 1 | 9.74 |
| CHEMBL443020 | — | — | 1 | 9.66 |
| CHEMBL100710 | — | — | 1 | 9.66 |
| CHEMBL101268 | — | — | 1 | 9.59 |
| CHEMBL101995 | — | — | 1 | 9.59 |
| CHEMBL102103 | — | — | 1 | 9.55 |
| CHEMBL328425 | — | — | 1 | 9.41 |
| CHEMBL102048 | — | — | 1 | 9.41 |
| CHEMBL100444 | — | — | 1 | 9.24 |
| CHEMBL317186 | — | — | 1 | 9.20 |
| CHEMBL317519 | — | — | 1 | 9.11 |
| CHEMBL317943 | — | — | 1 | 9.11 |
| CHEMBL319833 | — | — | 1 | 9.04 |
| CHEMBL320207 | — | — | 1 | 8.96 |
| CHEMBL100185 | — | — | 1 | 8.96 |
| CHEMBL327522 | — | — | 1 | 8.96 |
| CHEMBL102093 | — | — | 1 | 8.85 |
| CHEMBL310675 | — | — | 1 | 8.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419165 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL316714 | — | IC50 | = | 0.014 | nM | 10.85 |
| CHEMBL101414 | — | IC50 | = | 0.022 | nM | 10.66 |
| CHEMBL102195 | — | IC50 | = | 0.029 | nM | 10.54 |
| CHEMBL100711 | — | IC50 | = | 0.039 | nM | 10.41 |
| CHEMBL431456 | — | IC50 | = | 0.046 | nM | 10.34 |
| CHEMBL317437 | — | IC50 | = | 0.065 | nM | 10.19 |
| CHEMBL328384 | — | IC50 | = | 0.082 | nM | 10.09 |
| CHEMBL320618 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL321766 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL320010 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL99373 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL431282 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL443020 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL100710 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL101268 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL101995 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL102103 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL328425 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL102048 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL100444 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL317186 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL317519 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL317943 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL319833 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL320207 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL100185 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL327522 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL102093 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL310675 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL316474 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL99857 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL100182 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL319900 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL319667 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL101064 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL100747 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL318509 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL433393 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL35670 | — | IC50 | = | 0.0052 | nM | - |
| CHEMBL319784 | — | IC50 | = | 0.009 | nM | - |