Assay Detail
Functional
CHEMBL699282
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Effective concentration required to inhibit growth of sub clone Hos colR cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HOS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Induction of reversible protein-linked DNA breaks in human osteogenic sarcoma cells by novel cytocidal colchicine derivatives which inhibit DNA topoisomerase II in vitro: Absence of cross-resistance in a colchicine-resistant sub-clone
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 4.57 | 4.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9892 | — | — | 1 | 4.58 |
| CHEMBL276677 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9892 | — | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL276677 | — | EC50 | = | 28000.0 | nM | 4.55 |