Assay Detail
Functional
CHEMBL699286
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In vitro ability to inhibit cholesterol biosynthesis in HepG2 cells in culture from [14C]acetate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HepG2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
(Aryloxy)methylsilane derivatives as new cholesterol biosynthesis inhibitors: synthesis and hypocholesterolemic activity of a new class of squalene epoxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.82 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27885 | — | — | 1 | 7.70 |
| CHEMBL107546 | — | — | 1 | 7.10 |
| CHEMBL323953 | — | — | 1 | 6.82 |
| CHEMBL1144 | PRAVASTATIN | 4.0 | 1 | 6.37 |
| CHEMBL326241 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27885 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL107546 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL323953 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1144 | PRAVASTATIN | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL326241 | — | IC50 | = | 800.0 | nM | 6.10 |