Assay Detail
Binding
CHEMBL699300
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Inhibitory activity against Integrase in 3'-end- processing
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.75 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37869 | — | — | 1 | 6.52 |
| CHEMBL36640 | — | — | 1 | 6.16 |
| CHEMBL289303 | — | — | 1 | 5.64 |
| CHEMBL39092 | — | — | 1 | 5.62 |
| CHEMBL39958 | — | — | 1 | 5.50 |
| CHEMBL36586 | — | — | 1 | 5.43 |
| CHEMBL37845 | — | — | 1 | 5.40 |
| CHEMBL39725 | — | — | 1 | - |
| CHEMBL36585 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37869 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL36640 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL289303 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL39092 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL39958 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL36586 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL37845 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL39725 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL36585 | — | IC50 | > | 100000.0 | nM | - |