Assay Detail
Binding
CHEMBL699301
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Inhibitory activity against HIV-1 integrase.
26
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
6-aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.51 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50605 | — | — | 2 | 6.52 |
| CHEMBL49201 | — | — | 2 | 5.16 |
| CHEMBL48381 | — | — | 2 | 5.12 |
| CHEMBL46032 | — | — | 2 | 4.66 |
| CHEMBL49473 | — | — | 2 | 4.42 |
| CHEMBL49387 | — | — | 2 | 4.35 |
| CHEMBL417356 | — | — | 2 | 4.30 |
| CHEMBL299873 | — | — | 2 | 4.30 |
| CHEMBL49363 | — | — | 2 | 4.25 |
| CHEMBL48573 | — | — | 2 | 4.21 |
| CHEMBL301161 | — | — | 2 | 4.14 |
| CHEMBL301183 | — | — | 2 | 4.12 |
| CHEMBL45578 | — | — | 2 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50605 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL50605 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL49201 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL48381 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL49201 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL48381 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL46032 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL49473 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL46032 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL49387 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL49473 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL417356 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL299873 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL49363 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL49387 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL48573 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL417356 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL299873 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL49363 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL48573 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL301161 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL301183 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL301161 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL45578 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL301183 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL45578 | — | IC50 | = | 95000.0 | nM | 4.02 |