Assay Detail
Binding
CHEMBL699303
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Inhibitory activity against HIV-1 integrase
39
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
HIV-1 integrase pharmacophore model derived from diverse classes of inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.22 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32865 | — | — | 1 | 8.00 |
| CHEMBL36070 | — | — | 1 | 7.40 |
| CHEMBL320261 | — | — | 1 | 7.23 |
| CHEMBL409132 | — | — | 1 | 7.16 |
| CHEMBL216058 | — | — | 1 | 7.05 |
| CHEMBL403498 | — | — | 1 | 7.00 |
| CHEMBL421353 | — | — | 1 | 6.90 |
| CHEMBL1159990 | — | — | 2 | 6.64 |
| CHEMBL1159993 | — | — | 1 | 6.58 |
| CHEMBL1159989 | — | — | 1 | 6.50 |
| CHEMBL32711 | — | — | 1 | 6.48 |
| CHEMBL1159988 | — | — | 1 | 6.44 |
| CHEMBL35842 | — | — | 1 | 6.43 |
| CHEMBL472863 | — | — | 1 | 6.43 |
| CHEMBL433434 | — | — | 1 | 6.22 |
| CHEMBL288097 | — | — | 1 | 6.22 |
| CHEMBL366356 | DIGALLIC ACID | — | 1 | 6.22 |
| CHEMBL36303 | — | — | 1 | 6.16 |
| CHEMBL3138501 | — | — | 1 | 6.01 |
| CHEMBL1159991 | — | — | 1 | 5.82 |
| CHEMBL285415 | — | — | 1 | 5.68 |
| CHEMBL284384 | — | — | 1 | 5.43 |
| CHEMBL369379 | — | — | 1 | 5.21 |
| CHEMBL285489 | — | — | 1 | 5.13 |
| CHEMBL36463 | — | — | 1 | 4.70 |
| CHEMBL285696 | — | — | 1 | 4.47 |
| CHEMBL33475 | — | — | 1 | 4.33 |
| CHEMBL32853 | — | — | 1 | - |
| CHEMBL368615 | — | — | 1 | - |
| CHEMBL287689 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32865 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL36070 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL320261 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL409132 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL216058 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL403498 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL421353 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL1159990 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1159993 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1159989 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL32711 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1159988 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL35842 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL472863 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1159990 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL366356 | DIGALLIC ACID | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL433434 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL288097 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL36303 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3138501 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL1159991 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL285415 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL284384 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL369379 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL285489 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL36463 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL285696 | — | IC50 | = | 33600.0 | nM | 4.47 |
| CHEMBL33475 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL33193 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL441600 | — | IC50 | > | 293000.0 | nM | - |
| CHEMBL32747 | — | IC50 | = | 123000.0 | nM | - |
| CHEMBL32810 | — | IC50 | = | 325000.0 | nM | - |
| CHEMBL284144 | — | IC50 | = | 331000.0 | nM | - |
| CHEMBL32853 | — | IC50 | = | 322000.0 | nM | - |
| CHEMBL35109 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL32804 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL287689 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL367553 | — | IC50 | = | 182200.0 | nM | - |
| CHEMBL368615 | — | IC50 | = | 224000.0 | nM | - |