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Assay Detail

CHEMBL699308

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Binding
Inhibitory concentration against HIV-1 integrase by strand transfer method
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 1
Confidence 9 — Direct single protein target
Curated By Expert

Target

Human immunodeficiency virus type 1 integrase (CHEMBL3471)
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.
Nicklaus MC, Neamati N, Hong H, Mazumder A, Sunder S, Chen J, Milne GW, Pommier Y.
J Med Chem (1997) 40 : 920 -929
PubMed 9083480 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 61 4.88 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL413552 QUERCETAGETIN 1 7.00
CHEMBL144613 1 6.54
CHEMBL367939 1 5.57
CHEMBL128740 1 5.06
CHEMBL319244 CAFFEIC ACID PHENETHYL ESTER 1 5.00
CHEMBL176619 1 4.86
CHEMBL440016 1 4.85
CHEMBL366434 1 4.84
CHEMBL172888 1 4.72
CHEMBL338145 1 4.63
CHEMBL173234 1 4.35
CHEMBL368800 1 4.21
CHEMBL421450 1 4.19
CHEMBL127388 1 4.11
CHEMBL174460 1 4.10
CHEMBL340865 1 4.02
CHEMBL176639 1 -
CHEMBL175003 1 -
CHEMBL173385 1 -
CHEMBL368602 1 -
CHEMBL609936 1 -
CHEMBL172993 1 -
CHEMBL172958 1 -
CHEMBL177200 1 -
CHEMBL173097 1 -
CHEMBL129055 1 -
CHEMBL369845 1 -
CHEMBL367419 1 -
CHEMBL368453 1 -
CHEMBL172148 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL413552 QUERCETAGETIN IC50 = 100.0 nM 7.00
CHEMBL144613 IC50 = 290.0 nM 6.54
CHEMBL367939 IC50 = 2700.0 nM 5.57
CHEMBL128740 IC50 = 8800.0 nM 5.06
CHEMBL319244 CAFFEIC ACID PHENETHYL ESTER IC50 = 10000.0 nM 5.00
CHEMBL176619 IC50 = 13700.0 nM 4.86
CHEMBL440016 IC50 = 14000.0 nM 4.85
CHEMBL366434 IC50 = 14300.0 nM 4.84
CHEMBL172888 IC50 = 19000.0 nM 4.72
CHEMBL338145 IC50 = 23600.0 nM 4.63
CHEMBL173234 IC50 = 44600.0 nM 4.35
CHEMBL368800 IC50 = 61000.0 nM 4.21
CHEMBL421450 IC50 = 65000.0 nM 4.19
CHEMBL127388 IC50 = 77000.0 nM 4.11
CHEMBL174460 IC50 = 80000.0 nM 4.10
CHEMBL340865 IC50 = 96000.0 nM 4.02
CHEMBL366481 IC50 > 200000.0 nM -
CHEMBL367059 IC50 > 200000.0 nM -
CHEMBL173696 IC50 > 200000.0 nM -
CHEMBL608787 IC50 > 200000.0 nM -
CHEMBL367265 IC50 > 200000.0 nM -
CHEMBL435891 IC50 > 200000.0 nM -
CHEMBL366739 IC50 > 200000.0 nM -
CHEMBL426583 IC50 > 200000.0 nM -
CHEMBL176555 IC50 > 200000.0 nM -
CHEMBL176417 IC50 > 200000.0 nM -
CHEMBL368451 IC50 > 200000.0 nM -
CHEMBL369213 IC50 > 200000.0 nM -
CHEMBL174023 IC50 > 200000.0 nM -
CHEMBL173691 IC50 > 200000.0 nM -
CHEMBL368650 IC50 > 200000.0 nM -
CHEMBL175107 IC50 > 200000.0 nM -
CHEMBL341067 IC50 = 178000.0 nM -
CHEMBL173097 IC50 > 200000.0 nM -
CHEMBL176639 IC50 > 200000.0 nM -
CHEMBL175003 IC50 > 200000.0 nM -
CHEMBL173385 IC50 > 200000.0 nM -
CHEMBL368602 IC50 > 200000.0 nM -
CHEMBL609936 IC50 > 200000.0 nM -
CHEMBL172993 IC50 > 200000.0 nM -
CHEMBL172958 IC50 = 112000.0 nM -
CHEMBL177200 IC50 > 200000.0 nM -
CHEMBL281997 IC50 > 200000.0 nM -
CHEMBL129055 IC50 = 142900.0 nM -
CHEMBL369845 IC50 > 200000.0 nM -
CHEMBL367419 IC50 > 200000.0 nM -
CHEMBL368453 IC50 > 200000.0 nM -
CHEMBL172148 IC50 > 200000.0 nM -
CHEMBL173548 IC50 > 200000.0 nM -
CHEMBL369592 IC50 > 200000.0 nM -