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Assay Detail

CHEMBL699379

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Functional
In vitro cytotoxicity against mouse J774 macrophages.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type J774
Confidence 1 — Organism
Curated By Expert

Target

J774 (CHEMBL614123)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania.
Bhattacharya G, Herman J, Delfín D, Salem MM, Barszcz T, Mollet M, Riccio G, Brun R, Werbovetz KA.
J Med Chem (2004) 47 : 1823 -1832
PubMed 15027874 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.06 9.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3349894 ANSAMITOCIN P3 1 9.33
CHEMBL298564 1 5.29
CHEMBL51746 1 5.14
CHEMBL53033 1 5.06
CHEMBL298557 1 5.00
CHEMBL52182 1 4.96
CHEMBL298397 1 4.96
CHEMBL55225 1 4.92
CHEMBL54952 1 4.82
CHEMBL52597 1 4.80
CHEMBL298774 1 4.60
CHEMBL53153 1 4.55
CHEMBL54551 1 4.51
CHEMBL295960 ORYZALIN 1 4.36
CHEMBL54094 1 4.35
CHEMBL53698 1 4.32
CHEMBL52478 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3349894 ANSAMITOCIN P3 IC50 = 0.47 nM 9.33
CHEMBL298564 IC50 = 5100.0 nM 5.29
CHEMBL51746 IC50 = 7200.0 nM 5.14
CHEMBL53033 IC50 = 8700.0 nM 5.06
CHEMBL298557 IC50 = 10000.0 nM 5.00
CHEMBL52182 IC50 = 11000.0 nM 4.96
CHEMBL298397 IC50 = 11000.0 nM 4.96
CHEMBL55225 IC50 = 12000.0 nM 4.92
CHEMBL54952 IC50 = 15000.0 nM 4.82
CHEMBL52597 IC50 = 16000.0 nM 4.80
CHEMBL298774 IC50 = 25000.0 nM 4.60
CHEMBL53153 IC50 = 28000.0 nM 4.55
CHEMBL54551 IC50 = 31000.0 nM 4.51
CHEMBL295960 ORYZALIN IC50 = 44000.0 nM 4.36
CHEMBL54094 IC50 = 45000.0 nM 4.35
CHEMBL53698 IC50 = 48000.0 nM 4.32
CHEMBL52478 IC50 > 100000.0 nM -