Assay Detail
Binding
CHEMBL699441
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In vitro inhibition of recombinant integrase activity in a standard 3'-processing assay.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.46 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36640 | — | — | 1 | 6.16 |
| CHEMBL312608 | — | — | 1 | 6.05 |
| CHEMBL82986 | — | — | 1 | 5.82 |
| CHEMBL289303 | — | — | 1 | 5.64 |
| CHEMBL39092 | — | — | 1 | 5.62 |
| CHEMBL310321 | — | — | 1 | 5.52 |
| CHEMBL39958 | — | — | 1 | 5.50 |
| CHEMBL82633 | — | — | 1 | 5.30 |
| CHEMBL81182 | — | — | 1 | 5.30 |
| CHEMBL81714 | — | — | 1 | 5.30 |
| CHEMBL40148 | — | — | 1 | 5.28 |
| CHEMBL80008 | — | — | 1 | 5.19 |
| CHEMBL83746 | — | — | 1 | 5.19 |
| CHEMBL420026 | — | — | 1 | 4.52 |
| CHEMBL309885 | — | — | 1 | - |
| CHEMBL81284 | — | — | 1 | - |
| CHEMBL82359 | — | — | 1 | - |
| CHEMBL83419 | — | — | 1 | - |
| CHEMBL82029 | — | — | 1 | - |
| CHEMBL81686 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36640 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL312608 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL82986 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL289303 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL39092 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL310321 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL39958 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL82633 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL81182 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL81714 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL40148 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL80008 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL83746 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL420026 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL309885 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL81284 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL82359 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL83419 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL82029 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL81686 | — | IC50 | > | 100000.0 | nM | - |