Assay Detail
Binding
CHEMBL699442
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Inhibition of rous sarcoma virus (RSV) Integrase.
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rous sarcoma virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gag-Pol polyprotein (CHEMBL2750) ↗| Type | SINGLE PROTEIN |
| Organism | Rous sarcoma virus (strain Prague C) (RSV-PrC) |
Publication
Modeling of the inhibition of retroviral integrases by styrylquinoline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.89 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37869 | — | — | 1 | 5.68 |
| CHEMBL39092 | — | — | 1 | 5.64 |
| CHEMBL59548 | — | — | 1 | 5.13 |
| CHEMBL40148 | — | — | 1 | 4.99 |
| CHEMBL418613 | — | — | 1 | 4.68 |
| CHEMBL59446 | — | — | 1 | 4.42 |
| CHEMBL36586 | — | — | 1 | 4.42 |
| CHEMBL58057 | — | — | 1 | 4.19 |
| CHEMBL293788 | — | — | 1 | - |
| CHEMBL418303 | — | — | 1 | - |
| CHEMBL61203 | — | — | 1 | - |
| CHEMBL58191 | — | — | 1 | - |
| CHEMBL61800 | — | — | 1 | - |
| CHEMBL58923 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37869 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL39092 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL59548 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL40148 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL418613 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL59446 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL36586 | — | IC50 | = | 38300.0 | nM | 4.42 |
| CHEMBL58057 | — | IC50 | = | 65100.0 | nM | 4.19 |
| CHEMBL293788 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL418303 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL61203 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL58191 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL61800 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL58923 | — | IC50 | > | 100000.0 | nM | - |