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Assay Detail

CHEMBL699455

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity in Ishikawa human endometrial cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Ishikawa
Confidence 1 — Organism
Curated By Expert

Target

Ishikawa (CHEMBL614649)
Type CELL-LINE
Organism Homo sapiens

Publication

Bone targeted drugs 2. synthesis of estrogens with hydroxyapatite affinity
Willson TM, Henke BR, Momtahen TM, Garrison DT, Moore LB, Geddie NG, Baer PG
Bioorg Med Chem Lett (1996) 6 : 1047 -1050
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 4 6.62 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL9225 HEXESTROL 4.0 1 10.00
CHEMBL266377 1 5.96
CHEMBL267891 1 5.80
CHEMBL9428 1 4.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL9225 HEXESTROL EC50 = 0.1 nM 10.00
CHEMBL266377 EC50 = 1100.0 nM 5.96
CHEMBL267891 EC50 = 1600.0 nM 5.80
CHEMBL9428 EC50 = 20000.0 nM 4.70