Assay Detail
Functional
CHEMBL699474
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Effective concentration for agonist activity in guinea pig ileum whole segment
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.37 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275035 | — | — | 1 | 7.24 |
| CHEMBL11553 | — | — | 1 | 7.08 |
| CHEMBL274831 | — | — | 1 | 6.83 |
| CHEMBL275507 | — | — | 1 | 6.74 |
| CHEMBL11879 | — | — | 1 | 6.53 |
| CHEMBL11515 | — | — | 1 | 6.52 |
| CHEMBL11603 | — | — | 1 | 5.59 |
| CHEMBL11584 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275035 | — | EC50 | = | 57.54 | nM | 7.24 |
| CHEMBL11553 | — | EC50 | = | 83.18 | nM | 7.08 |
| CHEMBL274831 | — | EC50 | = | 147.91 | nM | 6.83 |
| CHEMBL275507 | — | EC50 | = | 181.97 | nM | 6.74 |
| CHEMBL11879 | — | EC50 | = | 295.12 | nM | 6.53 |
| CHEMBL11515 | — | EC50 | = | 302.0 | nM | 6.52 |
| CHEMBL11603 | — | EC50 | = | 2570.4 | nM | 5.59 |
| CHEMBL11584 | — | EC50 | = | 40738.03 | nM | 4.39 |