Assay Detail
Binding
CHEMBL699509
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Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 1&2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.91 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177021 | — | — | 1 | 5.36 |
| CHEMBL366861 | FUMARPROTOCETRARIC ACID | — | 1 | 5.34 |
| CHEMBL366410 | — | — | 1 | 5.19 |
| CHEMBL171637 | PHYSODIC ACID | — | 1 | 4.51 |
| CHEMBL113835 | — | — | 1 | 4.16 |
| CHEMBL367881 | (+)-USNIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177021 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL366861 | FUMARPROTOCETRARIC ACID | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL366410 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL171637 | PHYSODIC ACID | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL113835 | — | IC50 | = | 68500.0 | nM | 4.16 |
| CHEMBL367881 | (+)-USNIC ACID | IC50 | = | 123700.0 | nM | - |