Assay Detail
Binding
CHEMBL699510
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Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 2
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 4.84 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366356 | DIGALLIC ACID | — | 1 | 6.22 |
| CHEMBL177126 | — | — | 1 | 6.16 |
| CHEMBL175266 | — | — | 1 | 6.05 |
| CHEMBL174366 | — | — | 1 | 5.80 |
| CHEMBL173530 | STICTIC ACID | — | 1 | 5.72 |
| CHEMBL285415 | — | — | 1 | 5.57 |
| CHEMBL174150 | — | — | 1 | 5.40 |
| CHEMBL172439 | SLAZINIC ACID | — | 1 | 5.21 |
| CHEMBL369379 | — | — | 1 | 5.21 |
| CHEMBL366861 | FUMARPROTOCETRARIC ACID | — | 1 | 5.14 |
| CHEMBL172418 | — | — | 1 | 5.10 |
| CHEMBL176570 | PSOROMIC ACID | — | 1 | 4.91 |
| CHEMBL174041 | — | — | 1 | 4.70 |
| CHEMBL116973 | — | — | 1 | 4.64 |
| CHEMBL368123 | — | — | 1 | 4.61 |
| CHEMBL354416 | — | — | 1 | 4.57 |
| CHEMBL368810 | — | — | 1 | 4.55 |
| CHEMBL355757 | — | — | 1 | 4.50 |
| CHEMBL284616 | CHLOROGENIC ACID | 2.0 | 1 | 4.50 |
| CHEMBL176916 | — | — | 1 | 4.45 |
| CHEMBL170358 | — | — | 1 | 4.41 |
| CHEMBL173117 | — | — | 1 | 4.39 |
| CHEMBL173698 | — | — | 1 | 4.36 |
| CHEMBL173978 | — | — | 1 | 4.30 |
| CHEMBL177054 | — | — | 1 | 4.29 |
| CHEMBL17377 | FOSTRIECIN | 2.0 | 1 | 4.28 |
| CHEMBL368859 | — | — | 1 | 4.26 |
| CHEMBL176754 | — | — | 1 | 4.26 |
| CHEMBL172018 | — | — | 1 | 4.26 |
| CHEMBL115145 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366356 | DIGALLIC ACID | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL177126 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL175266 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL174366 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL173530 | STICTIC ACID | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL285415 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL174150 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL172439 | SLAZINIC ACID | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL369379 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL366861 | FUMARPROTOCETRARIC ACID | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL172418 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL176570 | PSOROMIC ACID | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL174041 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL116973 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL368123 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL354416 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL368810 | — | IC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL355757 | — | IC50 | = | 31700.0 | nM | 4.50 |
| CHEMBL284616 | CHLOROGENIC ACID | IC50 | = | 31300.0 | nM | 4.50 |
| CHEMBL176916 | — | IC50 | = | 35800.0 | nM | 4.45 |
| CHEMBL170358 | — | IC50 | = | 38600.0 | nM | 4.41 |
| CHEMBL173117 | — | IC50 | = | 40500.0 | nM | 4.39 |
| CHEMBL173698 | — | IC50 | = | 43300.0 | nM | 4.36 |
| CHEMBL173978 | — | IC50 | = | 49500.0 | nM | 4.30 |
| CHEMBL177054 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL17377 | FOSTRIECIN | IC50 | = | 52700.0 | nM | 4.28 |
| CHEMBL368859 | — | IC50 | = | 54800.0 | nM | 4.26 |
| CHEMBL172018 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL176754 | — | IC50 | = | 54400.0 | nM | 4.26 |
| CHEMBL115145 | — | IC50 | = | 57800.0 | nM | 4.24 |
| CHEMBL175052 | — | IC50 | = | 76600.0 | nM | 4.12 |
| CHEMBL368615 | — | IC50 | = | 224000.0 | nM | - |
| CHEMBL368805 | — | IC50 | = | 128700.0 | nM | - |
| CHEMBL367553 | — | IC50 | = | 182200.0 | nM | - |
| CHEMBL113891 | — | IC50 | < | 23400.0 | nM | - |