Assay Detail
Binding
CHEMBL699514
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested or its affinity against ionotropic glutamate receptor ionotropic kainate in rats
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate (CHEMBL2094119) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Bioisosteric replacement of the alpha-amino carboxylic acid functionality in 2-amino-5-phosphonopentanoic acid yields unique 3,4-diamino-3-cyclobutene-1,2-dione containing NMDA antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.82 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279956 | QUISQUALATE | — | 1 | 6.82 |
| CHEMBL143738 | — | — | 1 | - |
| CHEMBL358649 | — | — | 1 | - |
| CHEMBL141335 | — | — | 1 | - |
| CHEMBL142208 | — | — | 1 | - |
| CHEMBL142206 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279956 | QUISQUALATE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL143738 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL358649 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL141335 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL142208 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL142206 | — | IC50 | > | 100000.0 | nM | - |