Assay Detail
Functional
CHEMBL699520
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Inhibition of thrombin-induced human gel-filtered platelet aggregation
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1,2,4-triazolo[3,4-a]pyridine as a novel, constrained template for fibrinogen receptor (GPIIb/IIIa) antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 10.01 | 10.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL315008 | — | — | 1 | 10.80 |
| CHEMBL421547 | — | — | 1 | 10.57 |
| CHEMBL329015 | — | — | 1 | 10.39 |
| CHEMBL329871 | — | — | 1 | 10.37 |
| CHEMBL88944 | — | — | 1 | 10.24 |
| CHEMBL87728 | ELAROFIBAN | 2.0 | 1 | 10.22 |
| CHEMBL328528 | — | — | 1 | 10.21 |
| CHEMBL88826 | — | — | 1 | 10.17 |
| CHEMBL89424 | — | — | 1 | 9.92 |
| CHEMBL315637 | — | — | 1 | 9.43 |
| CHEMBL314318 | — | — | 1 | 9.22 |
| CHEMBL89249 | — | — | 1 | 8.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL315008 | — | IC50 | = | 0.016 | nM | 10.80 |
| CHEMBL421547 | — | IC50 | = | 0.027 | nM | 10.57 |
| CHEMBL329015 | — | IC50 | = | 0.041 | nM | 10.39 |
| CHEMBL329871 | — | IC50 | = | 0.043 | nM | 10.37 |
| CHEMBL88944 | — | IC50 | = | 0.057 | nM | 10.24 |
| CHEMBL87728 | ELAROFIBAN | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL328528 | — | IC50 | = | 0.061 | nM | 10.21 |
| CHEMBL88826 | — | IC50 | = | 0.068 | nM | 10.17 |
| CHEMBL89424 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL315637 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL314318 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL89249 | — | IC50 | = | 2.7 | nM | 8.57 |