Assay Detail
Functional
CHEMBL699522
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Inhibition of ADP-mediated platelet aggregation in human gel-filtered platelets
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Non-peptide fibrinogen receptor antagonists. 3. design and discovery of a centrally constrained inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.90 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL916 | TIROFIBAN | 4.0 | 1 | 8.00 |
| CHEMBL51701 | — | — | 1 | 6.28 |
| CHEMBL54038 | — | — | 1 | 5.96 |
| CHEMBL53084 | — | — | 1 | 5.80 |
| CHEMBL52240 | — | — | 1 | 5.70 |
| CHEMBL299947 | — | — | 1 | 5.00 |
| CHEMBL265628 | — | — | 1 | 4.58 |
| CHEMBL441613 | — | — | 1 | - |
| CHEMBL32960 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL916 | TIROFIBAN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL51701 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL54038 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL53084 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL52240 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL299947 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL265628 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL441613 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL32960 | — | IC50 | = | 25.0 | nM | - |