Assay Detail
Binding
CHEMBL699556
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Inhibitory activity against inosine monophosphate dehydrogenase IMPDH II
36
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Inosine-5'-monophosphate dehydrogenase 2 (CHEMBL2002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.71 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153794 | — | — | 1 | 8.30 |
| CHEMBL153118 | — | — | 1 | 8.22 |
| CHEMBL422508 | — | — | 3 | 8.22 |
| CHEMBL304087 | MERIMEPODIB | 2.0 | 1 | 8.00 |
| CHEMBL423952 | — | — | 1 | 7.96 |
| CHEMBL155617 | — | — | 1 | 7.92 |
| CHEMBL357309 | — | — | 1 | 7.92 |
| CHEMBL153389 | — | — | 1 | 7.89 |
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 7.85 |
| CHEMBL154752 | — | — | 1 | 7.85 |
| CHEMBL357949 | — | — | 1 | 7.85 |
| CHEMBL359344 | — | — | 1 | 7.82 |
| CHEMBL357291 | — | — | 1 | 7.82 |
| CHEMBL434894 | — | — | 1 | 7.82 |
| CHEMBL149699 | — | — | 1 | 7.80 |
| CHEMBL153516 | — | — | 1 | 7.75 |
| CHEMBL154867 | — | — | 1 | 7.75 |
| CHEMBL153411 | — | — | 1 | 7.70 |
| CHEMBL153773 | — | — | 1 | 7.68 |
| CHEMBL149755 | — | — | 1 | 7.68 |
| CHEMBL153702 | — | — | 1 | 7.60 |
| CHEMBL153429 | — | — | 1 | 7.58 |
| CHEMBL153247 | — | — | 1 | 7.55 |
| CHEMBL155616 | — | — | 1 | 7.52 |
| CHEMBL153175 | — | — | 1 | 7.48 |
| CHEMBL152978 | — | — | 1 | 7.28 |
| CHEMBL150631 | — | — | 1 | 7.26 |
| CHEMBL153595 | — | — | 1 | 7.17 |
| CHEMBL153771 | — | — | 1 | 7.08 |
| CHEMBL152931 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153794 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL153118 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL422508 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL304087 | MERIMEPODIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL423952 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL155617 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL357309 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL153389 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL357949 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL154752 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL866 | MYCOPHENOLIC ACID | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL359344 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL357291 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL434894 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL149699 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL153516 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL154867 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL153411 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL153773 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL149755 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL153702 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL153429 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL153247 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL155616 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL153175 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL152978 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL150631 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL153595 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL153771 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL152931 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL153481 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL151060 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL422508 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL422508 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL356881 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL356236 | — | IC50 | < | 10.0 | nM | - |