Assay Detail
Binding
CHEMBL699558
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Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzyme
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Inosine-5'-monophosphate dehydrogenase 2 (CHEMBL2002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3-cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.96 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118988 | — | — | 1 | 8.22 |
| CHEMBL109312 | — | — | 1 | 8.15 |
| CHEMBL112967 | — | — | 1 | 7.96 |
| CHEMBL304087 | MERIMEPODIB | 2.0 | 1 | 7.96 |
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 7.82 |
| CHEMBL64639 | — | — | 1 | 7.80 |
| CHEMBL64830 | — | — | 1 | 7.80 |
| CHEMBL331535 | — | — | 1 | 7.48 |
| CHEMBL119408 | — | — | 1 | 7.40 |
| CHEMBL118714 | — | — | 1 | 7.08 |
| CHEMBL119208 | — | — | 1 | 7.03 |
| CHEMBL109335 | — | — | 1 | 7.03 |
| CHEMBL119655 | — | — | 1 | 7.00 |
| CHEMBL333901 | — | — | 1 | 6.89 |
| CHEMBL119407 | — | — | 1 | 6.75 |
| CHEMBL120656 | — | — | 1 | 6.75 |
| CHEMBL327031 | — | — | 1 | 6.70 |
| CHEMBL118115 | — | — | 1 | 6.68 |
| CHEMBL323943 | — | — | 1 | 6.64 |
| CHEMBL118260 | — | — | 1 | 6.62 |
| CHEMBL116596 | — | — | 1 | 6.58 |
| CHEMBL333662 | — | — | 1 | 6.58 |
| CHEMBL118664 | — | — | 1 | 6.58 |
| CHEMBL333483 | — | — | 1 | 6.55 |
| CHEMBL116208 | — | — | 1 | 6.54 |
| CHEMBL117408 | — | — | 1 | 6.40 |
| CHEMBL118983 | — | — | 1 | 6.38 |
| CHEMBL118384 | — | — | 1 | 6.38 |
| CHEMBL119114 | — | — | 1 | 6.36 |
| CHEMBL118613 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118988 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL109312 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL304087 | MERIMEPODIB | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL112967 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL866 | MYCOPHENOLIC ACID | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL64639 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL64830 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL331535 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL119408 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL118714 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL119208 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL109335 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL119655 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL333901 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL120656 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL119407 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL327031 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL118115 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL323943 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL118260 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL116596 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL333662 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL118664 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL333483 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL116208 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL117408 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL118384 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL118983 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL119114 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL118613 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL333482 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL118899 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL65013 | — | IC50 | = | 19000.0 | nM | - |
| CHEMBL118951 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL118306 | — | IC50 | > | 5000000.0 | nM | - |
| CHEMBL332758 | — | IC50 | > | 550.0 | nM | - |