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Assay Detail

CHEMBL699559

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Binding
Inhibitory concentration against Inosine-5'-monophosphate dehydrogenase 2 was determined
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Inosine-5'-monophosphate dehydrogenase 2 (CHEMBL2002)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The TosMIC approach to 3-(oxazol-5-yl) indoles: application to the synthesis of indole-based IMPDH inhibitors.
Dhar TG, Shen Z, Fleener CA, Rouleau KA, Barrish JC, Hollenbaugh DL, Iwanowicz EJ.
Bioorg Med Chem Lett (2002) 12 : 3305 -3308
PubMed 12392738 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 7.42 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL109312 1 8.15
CHEMBL112967 1 7.96
CHEMBL866 MYCOPHENOLIC ACID 4.0 1 7.82
CHEMBL64830 1 7.80
CHEMBL116061 1 7.46
CHEMBL112405 1 7.46
CHEMBL113572 1 7.42
CHEMBL112993 1 7.40
CHEMBL423873 1 7.11
CHEMBL109335 1 7.03
CHEMBL112444 1 6.70
CHEMBL324781 1 6.69
CHEMBL110005 1 -
CHEMBL65013 1 -
CHEMBL109324 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL109312 IC50 = 7.0 nM 8.15
CHEMBL112967 IC50 = 11.0 nM 7.96
CHEMBL866 MYCOPHENOLIC ACID IC50 = 15.0 nM 7.82
CHEMBL64830 IC50 = 16.0 nM 7.80
CHEMBL116061 IC50 = 35.0 nM 7.46
CHEMBL112405 IC50 = 35.0 nM 7.46
CHEMBL113572 IC50 = 38.0 nM 7.42
CHEMBL112993 IC50 = 40.0 nM 7.40
CHEMBL423873 IC50 = 77.0 nM 7.11
CHEMBL109335 IC50 = 93.0 nM 7.03
CHEMBL112444 IC50 = 200.0 nM 6.70
CHEMBL324781 IC50 = 205.0 nM 6.69
CHEMBL110005 IC50 > 5000.0 nM -
CHEMBL65013 IC50 = 19000.0 nM -
CHEMBL109324 IC50 > 5000.0 nM -